Publication alert: Targeted optical uncaging of an adenosine A1 receptor agonist regulates excitability of hippocampal slices derived from epileptic mice.
We are pleased to share a new publication from the 4BRAIN team investigating a targeted approach to regulate neuronal excitability in epilepsy.
The study, “Targeted optical uncaging of an adenosine A1 receptor agonist regulates excitability of hippocampal slices derived from epileptic mice,” explores the use of photopharmacology to activate adenosine A1 receptors with precise spatial and temporal control. Using hippocampal slices from epileptic mice, the researchers investigated how locally activated A1 receptors can modulate neuronal activity.
This work builds on our previous research into the use of photocaged adenosine A1 receptor agonists for controlling neuronal activity and seizures, further highlighting the potential of photopharmacology as a targeted strategy for epilepsy research.
Read more about this publication and our other research on the Research4BRAIN Publications page.
Authors: Marijke Vergaelen, Kristl Vonck, Ruben Tack, Melissa Lajtos, Simona Manzella, Jeroen Missinne, Mathieu Sprengers, Evelien Carrette, Paul Boon, Serge Van Calenbergh, Robrecht Raedt
